Work

Independent validation of transgenerational inheritance of learned pathogen avoidance in Caenorhabditis elegans

Year: 2025

Type: preprint

Abstract: Previously, it was shown that learned avoidance of Pseudomonas aeruginosa PA14 in Caenorhabditis elegans can be transmitted to untrained offspring (Kaletsky et al., 2025). Here, we show an independent validation of this phenomenon under the originally specified assay conditions. Adapting the Murphy lab protocol, worms trained on PA14 develop significant avoidance that persists in F1 and F2 generations, with reduced magnitude after P0. These results align with the Murphy group’s findings and address a recent report from the Hunter group that did not detect persistence beyond F1.

Source: eLife

DOI: 10.7554/elife.107034

Authors: Aalimah Akinosho, Joseph Alexander, Kyle Floyd, Andres Gabriel Vidal-Gadea

Institution: Illinois State University

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500