Abstract 1730 PTHrP Negatively Effects Ethanol-induced Proliferation and Migration of Mammary Epithelial Cells
Year: 2025
Type: conference-abstract
Abstract: Alcohol consumption is associated with an increased risk of breast cancer. Several mechanisms involving alcohol-induced breast cancer have been suggested including increased estrogen induced cell proliferation and migration. In the present study we were interested in determining the effect of alcohol on the pubertal development of the mammary gland, a period of intense estrogen-induced growth. Three-week old WT mice fed a liquid diet consisting of 0, 10 and 20% ethanol showed an increase in epithelial density and proliferation at the terminal end bud (TEB), as shown by whole mount analysis and BrdU incorporation.
Source: Journal of Biological Chemistry
Authors: Maureen Dunbar, Hayden Perrone, Ivan Shibley
Institution: Pennsylvania State University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,430
OpenAlex ID: W4411258067