Overall Survival After Allogeneic Transplantation in Advanced Cutaneous T-Cell Lymphomas (CUTALLO): A Propensity Score–Matched Controlled Prospective Study
Year: 2025
Type: article
Abstract: Cutaneous T-cell lymphomas (CTCLs) are rare, usually refractory, and sometimes fatal diseases. Patients presenting with advanced-stage CTCL usually exhibit poor long-term survival outcomes. Only very few treatments have improved progression-free survival (PFS) in advanced CTCL, and no treatment has increased overall survival (OS). In 2023, the results of the CUTALLO trial supported the hypothesis that hematopoietic stem-cell transplantation (HSCT) was associated with significantly longer PFS as compared with standard-of-care treatment among advanced-stage patients although HSCT did not significantly affect OS. We provide herein the final OS data pertaining to the same patient population after a longer median follow-up of 38.9 months. Of the 99 patients included in the analysis, 55 (56%) were assigned to the HSCT group, whereas 44 (44%) were allocated to the non-HSCT group. The updated survival analysis reported that 16 of 55 patients (29%) in the HSCT group and 22 of 44 patients (50%) in the non-HSCT group died. The median OS was not reached in the HSCT group and 51.5 months (95% CI, 26.9 to 51.5) in the non-HSCT group (hazard ratio, 0.40 [95% CI, 0.20 to 0.80]). Compared with the standard of care for advanced CTCL, after extended follow-up, allogeneic HSCT was associated with significantly longer OS.
Source: Journal of Clinical Oncology
DOI: 10.1200/jco-25-00183
Authors: Adèle de Masson, Marie Beylot-Barry, Caroline Ram-Wolff, Jean-Baptiste Mear, Stéphane Dalle, Jacques Rouanet, Saskia Ingen-Housz-Oro, Corentin Orvain, Julie Abraham, Olivier Dereure, Amandine Charbonnier, Jérôme Cornillon, Christine Longvert, Stéphane Barete, Serge Boulinguez, Ewa Wierzbicka-Hainaut, François Aubin, Marie-Thérèse Rubio, Marc Bernard, Aline Schmidt-Tanguy, Roch Houot, Anne Pham-Ledard, David Michonneau, Hélène Labussière-Wallet, Jean-David Bouaziz, Florent Grange, Hélène Moins-Teisserenc, Katayoun Jondeau, Samia Mourah, Maxime Battistella, Etienne Daguindau, Michael Loschi, Alexandra Picard, Nathalie Franck, Natacha Maillard, Anne Huynh, Stéphanie Nguyen, Ambroise Marçais, Guillaume Chaby, Patrice Ceballos, Yannick Le Corre, Sébastien Maury, Jacques-Olivier Bay, Henri Adamski, Emmanuel Bachy, Edouard Forcade, Gérard Socié, Martine Bagot, Sylvie Chevret, Régis Peffault de Latour, on behalf of CUTALLO Investigators, Groupe Français d’Etude des Lymphomes Cutanés and Société Française de Greffe de Moëlle et Thérapie Cellulaire, Pauline Brice, Laurence Michel
Institutions: Inserm, Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Louis, Institut de recherche Saint-Louis, Université de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, BoRdeaux Institute of onCology, Hôpital Pontchaillou, Centre Hospitalier Universitaire de Rennes, Hôpital Lyon Sud, Centre Hospitalier Universitaire de Clermont-Ferrand, Université Paris-Est Créteil, Hôpitaux Universitaires Henri-Mondor, Centre National de la Recherche Scientifique, Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers, Centre Hospitalier Universitaire d'Angers, Université d'Angers, Nantes Université, Centre Hospitalier Universitaire de Limoges, Université de Montpellier, Centre Hospitalier Universitaire Amiens-Picardie, Centre Hospitalier Universitaire de Saint-Étienne, Hôpital Ambroise-Paré, Pitié-Salpêtrière Hospital, Centre Hospitalier Universitaire de Toulouse, Centre Hospitalier Universitaire de Poitiers, Centre Hospitalier Universitaire de Besançon, Centre Hospitalier Régional et Universitaire de Nancy, Ingénierie Moléculaire, Cellulaire et Physiopathologie, Université de Lorraine, Université de Rennes, Hospices Civils de Lyon, Centre Hospitalier de Valence, Centre Hospitalier Universitaire de Nice, Hôpital l'Archet, Hôpital Cochin, Institut universitaire du cancer de Toulouse Oncopole, Hôpital Necker-Enfants Malades, Centre Hospitalier Universitaire de Montpellier, Centre Hospitalier Universitaire Henri-Mondor
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Cancer Institute
OpenAlex ID: W4411260395