Work

Metastatic Prostate Ductal Adenocarcinoma Presenting as a Solitary Rectal Mucosal Polyp: A Case Report

Year: 2025

Type: article

Abstract: While prostate cancer is predominantly of the acinar subtype, ductal adenocarcinoma is a rare variant that typically presents at an advanced stage, often with low prostate-specific antigen (PSA) levels and rare gastrointestinal metastases. We report the case of a 75-year-old male patient with a history of prostate cancer status post-prostatectomy who, during routine surveillance, exhibited a solitary rectal mucosal polyp. Imaging and colonoscopy identified an invasive carcinoma, mimicking rectal adenocarcinoma, but histologically and immunohistochemically consistent with metastatic prostate ductal adenocarcinoma, isolated to the rectum without other site involvement. The metastatic tumor was surgically removed initially, but local recurrence occurred within a year, and the recurrent tumor was treated with radiation therapy due to inoperability. This case highlights the need to consider metastatic tumor in a patient with a previous history in the differential diagnosis of solitary colorectal lesions and underscores the role of immunohistochemistry in accurate diagnosis and management.

Source: Cureus

DOI: 10.7759/cureus.85962

Authors: Lingling Xian, Wei Xin

Institution: University of South Alabama

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411262753