Work

Cone degeneration in two Shih Tzu dogs: clinical and genetic investigation

Year: 2025

Type: article

Abstract: ABSTRACT: Two cases of cone degeneration in adult Shih Tzu canine patients are reported herein. Definitive diagnosis was made based on the ophthalmic examination finding, typical clinical signs, and characteristic electroretinography results that demonstrated normal rod function and absence of recordable cone function. Sanger sequencing of the entire coding sequence of the cyclic nucleotide gated channel β3 (CNGB3) gene did not reveal disease causing variants in these dogs. To the authors’ knowledge, this is the first report of clinical, electroretinographic and genetic investigation of cone degeneration in Shih Tzu.

Source: Ciência Rural

DOI: 10.1590/0103-8478cr20240397

Authors: Tatiana Assunção de Moraes, Angélica de Mendonça Vaz Safatle, Erin Burnight, Budd Tucker, Gil Ben-Shlomo

Institutions: Universidade de São Paulo, University of Iowa, Cornell University

Language: English

Topic: Retinal Development and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $133