Work

X-linked polymorphisms in TLR7 and TLR8 genes are associated with protection against Chikungunya fever

Year: 2025

Type: article

Abstract: BACKGROUND: Chikungunya virus (CHIKV) causes an infection that leads to the activation of the innate immune response, triggering receptor pathways such as toll-like receptors (TLRs). OBJECTIVE: The present study aimed to investigate the association of single nucleotide polymorphisms (SNPs) in genes encoding toll-like receptors 3, 7, and 8 and IRF5 in susceptibility to CHIKV infection and persistent joint pain. METHODS: A case-control study was carried out. The study included 121 symptomatic cases, 29 asymptomatic cases, and 182 healthy controls matched for age and sex. Polymorphisms were identified by TaqMan® SNP Genotyping assays. FINDINGS: The G allele of the TLR7 variant (rs3853839 G/C) and the G allele of TLR8 (rs3764879 G/C) were associated with protection against CHIKV infection [adjusted odd ratio (OR) = 0.64; p = 0.02 and adjusted OR = 0.54; p = 0.001, respectively]. Moreover, individuals who presented the G allele in the rs3764879 variant have a greater chance of developing the asymptomatic form (adjusted OR =2.88; p =0.004). The development of persistent joint pain was not associated with any investigated SNPs in positive anti-CHIKV IgG individuals. MAIN CONCLUSIONS: This study identified TLR7 and TLR8 gene polymorphisms as protective factors for Chikungunya infection.

Source: Memórias do Instituto Oswaldo Cruz

DOI: 10.1590/0074-02760230224