Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To assess the utility of nailfold video capillaroscopy (NVC) in patients diagnosed with acute and chronic graft versus host disease (GVHD) of the skin. Patients and Methods: Patients diagnosed with acute and chronic skin GVHD (n=11) and those without the diagnosis of GVHD (controls) (n=21) underwent NVC to assess capillary density, morphology, and hemorrhage. Statistical comparisons were made using Fisher's exact test. The study was performed from March 1, 2024, to August 1, 2024. Results: Patients diagnosed with acute and chronic GVHD were observed to have considerably more microhemorrhages, ramifications, and disorganized capillaries when compared with patients without a diagnosis of acute or chronic GVHD. Conclusion: This study reveals significant NVC abnormalities in patients with GVHD, suggesting distinct microvascular features that imply potential diagnostic value. The NVC may be a valuable tool for diagnosing and monitoring GVHD and warrants further investigation in larger cohorts.
Authors: Sehreen Mumtaz, Florentina Berianu, Puneet Bhullar, Jordan Phillipps, Madiha Iqbal, David Hodge, Breanna Cane, Olayemi Sokumbi
Institutions: Mayo Clinic in Florida, Mayo Clinic
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,000
OpenAlex ID: W4411273810