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Abstract 2601 Functional Crosstalk Between Ire1 and MAPK Slt2 Pathways via Transcription Factor Rlm1 in Yeast Saccharomyces cerevisiae

Year: 2025

Type: conference-abstract

Abstract: Almost one-third of cellular proteins fold and mature inside the endoplasmic reticulum (ER). If proteins fail to fold correctly or mis-fold, they accumulate in the ER, leading to a condition known as ER stress. This stress disrupts cellular protein homeostasis, or proteostasis. To restore ER proteostasis, cells evoke an network of adaptive signalling pathways, collectively referred to as the unfolded protein response (UPR). In the yeast Saccharomyces cerevisiae, the UPR is mediated by the ER-resident protein kinase/RNase Ire1 and a cytosolic mitogen-activated protein kinase (MAPK) Slt2.

Source: Journal of Biological Chemistry

Authors: Anish Chakraborty, Saswata Chakrabarty, Madhusudan Dey

Institution: University of Wisconsin–Milwaukee

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,430

Funders: Medical Research Council, National Health and Medical Research Council, Cancer Council Queensland

OpenAlex ID: W4411273971

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