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Metastatic Hepatocellular Carcinoma Presenting as a Large Abdominal Mass and Secondary Varicocele in a Hepatitis B Patient: A Case Report

Year: 2025

Type: article

Abstract: We report a rare and aggressive presentation of hepatocellular carcinoma in a 50-year-old man with a brief history of hepatitis B infection. The patient presented with a rapidly enlarging epigastric mass, recurrent hematemesis, and a newly developed left-sided varicocele. Imaging revealed a large exophytic hepatic mass with evidence of vascular displacement and intrahepatic metastases. Histopathological examination confirmed a diagnosis of poorly differentiated hepatocellular carcinoma. A multidisciplinary tumor board recommended palliative surgical debulking followed by systemic therapy to address tumor burden and improve quality of life. This case highlights the diagnostic and management challenges associated with atypical presentations of hepatocellular carcinoma in patients with minimal liver disease history.

Source: Cureus

DOI: 10.7759/cureus.85933

Authors: Mmahaletchumy Manoharan, Muhammad Hamza Shahid, Daniyal Abbasi, Lohana Pooja, Abdul Haseeb Hasan

Institutions: Universitas Sumatera Utara, Akhtar Saeed Medical and Dental College, Liaquat University of Medical & Health Sciences, Mayo Hospital

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411275178