Treatment patterns and blood count control in 10,112 patients with polycythemia vera
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Elevated blood counts in polycythemia vera (PV) are associated with increased thrombotic risk, which contribute to morbidity and mortality.Research design and methods This retrospective study describes treatment patterns and blood count control in patients with PV managed at community oncology practices (January 2014–February 2023; Integra Precision Q database).Results Of a total 10,112 patients, most received phlebotomy (68.1%) or hydroxyurea (HU; 28.2%) as initial treatment, with median follow-up of 32.1 (IQR, 13.5–58.5) months and 31.5 (IQR, 16.8–54.9) months, respectively. Changing treatment was less common than remaining on initial treatment despite 67.8% of patients on phlebotomy and 30.4% on HU having elevated hematocrit (≥45%) after 1 year of treatment. In contrast, 85.4% of patients who switched to ruxolitinib from HU achieved hematocrit < 45% after 1 year, and fewer required phlebotomy during ruxolitinib treatment than with HU treatment (RUX, 29.3%; HU, 53.5%). Additionally, 54.2% of patients who switched to ruxolitinib achieved white blood cell counts < 11 × 109/L, and 57.5% achieved platelet counts ≤ 400 × 109/L after 1 year of ruxolitinib treatment.Conclusions This real-world evidence highlights the importance of considering alternative therapies for patients whose initial treatment regimen does not provide adequate clinical benefit.
Source: Expert Review of Hematology
Authors: Naveen Pemmaraju, Jingbo Yu, Anupama Vasudevan, Husain Qureshi, Evan Braunstein, Aleksander Chojecki
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: Incyte
Award: G7944399959
OpenAlex ID: W4411276078