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Abstract 2610 Modified Carbapenem Derivatives exhibit Potential Inhibition against Mycobacterium tuberculosis Peptidoglycan Synthesis

Year: 2025

Type: conference-abstract

Abstract: Background: The burden of Tuberculosis (TB), has regained its position as the leading cause of death from a single infectious agent, Mycobacterium tuberculosis (Mtb) after COVID-19. Peptidoglycan synthesis is an underexplored drug target in Mtb treatment. Carbapenems are effective against TB as they are poor substrates for the Mtb β-lactamase BlaC and inhibit L, D-transpeptidases (LDTs), key β-lactam resistance mechanisms in Mtb. We hypothesize that substituting the C5α position and modifying the R2-side chain enhances carbapenem activity against Mtb.

Source: Journal of Biological Chemistry

Authors: Mary Nantongo, David Nguyen, Eunjeong Shin, Christopher Bethel, Magdalena Taracila, Khalid Dousa, Henry Boom, John Buynak, Robert Bonomo

Institution: Case Western Reserve University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,430

OpenAlex ID: W4411276417

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