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Baseline Keratin-18 Level And Risk Of Anti-Tuberculosis Drug-Induced Liver Injury: An Individual Matched Case-Control Study

Year: 2025

Type: article

Abstract: Anti-tuberculosis drug-induced liver injury (ATLI) presents a grand challenge to the global control of tuberculosis. Serum keratin-18 may have a certain predictive value for the occurrence of liver injury. The purpose of this study is to examine the correlation between baseline serum keratin-18 levels and ATLI risk among the eastern Chinese Han population. Employing a 1:2 individual matched case-control approach, the study encompassed 88 ATLI cases and 176 controls. Univariate and multivariate conditional logistic regression analyses were performed to evaluate the association between baseline keratin-18 levels and ATLI risk. Furthermore, area under the curve (AUC) was used to assess keratin-18's efficacy in distinguishing ATLI cases from controls. In ATLI cases, baseline keratin-18 levels were significantly lower than controls (188.8 vs. 234.9 ng/L, P = 0.044), with higher levels associated with reduced ATLI risk (OR = 0.995, 95% CI: 0.992-0.999, P = 0.005). Under the optimal keratin-18 cut-off value of 191.6 ng/L, the AUCs were equal to 0.577 (95% CI: 0.513-0.640, P = 0.018) in univariate analysis and 0.597 (95% CI: 0.524-0.670, P = 0.010) in multivariate analysis. The present study indicated that the higher the baseline keratin-18 concentration in tuberculosis patients of eastern Chinese Han population, the lower the risk of ATLI.

Source: Pakistan Journal of Pharmaceutical Sciences

DOI: 10.36721/pjps.2025.38.3.reg.12891.1

Author: Bing Han

Institution: Nanjing Medical University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China