Work

Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report

Year: 2025

Type: article

Abstract: Canine oral papillomatosis, caused by canine papilloma virus 1, is a benign condition primarily affecting young or immunosuppressed dogs. While most cases regress spontaneously, severe cases often require surgical intervention due to extensive lesions and associated discomforts. However, surgical excision is associated with a high risk of recurrence, necessitating adjuvant therapies. This report presents the case of a 1-year-old German Shepherd with severe oral papilloma unresponsive to prior treatments, managed through surgical excision followed by topical mitomycin C (MMC) application. MMC, applied intraoperatively and during follow-up, effectively prevented recurrence over a 1-year period. This case demonstrates the potential of MMC as an effective adjuvant therapy for severe canine oral papillomatosis, providing a novel approach in veterinary medicine.

Source: Veterinary Medicine and Science

DOI: 10.1002/vms3.70453

Authors: Jungyeon Yong, Myeongjee Kwon, Haerin Yoon, Sungin Lee, Kyung‐Mee Park

Institution: Chungbuk National University

Language: English

Topic: Veterinary Oncology Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,880