Epidemiological and Population Characteristics of Seroprevalence of TTIs Among Voluntary Blood Donors — Guangzhou City, Guangdong Province, China, 2014–2023
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Transfusion-transmitted infections (TTIs) pose significant public health challenges. Screening potential blood donors for hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Treponema pallidum (TP), along with ongoing monitoring of epidemiological data on TTIs among donors, is essential to ensure blood safety. Methods: This study conducted a retrospective analysis of the seroprevalence of HBsAg, anti-HCV, anti-HIV, and anti-TP among 3,111,265 blood donation events in Guangzhou from 2014 to 2023, investigating their relationships with demographic characteristics such as gender, age, and donation status. Results: The findings indicated that the overall seroprevalence of TTIs among blood donations was 866.21 per 100,000, demonstrating a declining trend over the ten-year period. Seroprevalence rates of transfusion-transmissible infections also exhibited a downward trend across various demographic groups. Notably, male donors, first-time donors, and older donors demonstrated higher seroprevalence rates for TTIs. Conclusions: While the overall seroprevalence rate of transfusion-transmissible infections among blood donors remains relatively low, significant disparities exist among different demographic groups. It is necessary of sustained TTIs monitoring among blood donors to guide public health interventions and donor screening practices.
Source: China CDC Weekly
Authors: Feifeng Li, Junmou Xie, Wenbo Gao, Fenfang Liao, Haojian Liang, Haojian Liang, Rongsong Du, Zhongping Li, Yongmei Nie, Yongshui Fu, Ru Xu, Shijie Li, Hao Wang, Huaqin Liang, Huaqin Liang
Language: English
Subfield: Management of Technology and Innovation
Domain: Social Sciences
Open Access status: diamond
OpenAlex ID: W4411286418