Work

Cell cycle and HIF-1 related gene expression alteration in thyroid cell lines under microgravity

Year: 2025

Type: article

Abstract: Background: With growing interest in space exploration, understanding microgravity's impact on human health is essential. This study aims to investigate gene expression changes and migration and invasion potential in five thyroid-related cell lines cultured under simulated microgravity. Methods: g) using a clinostat. Differentially expressed genes (DEGs) were analyzed using cDNA microarray, followed by functional annotation and assessment of aggressiveness via Transwell migration and invasion assays. Results: . Other conditions showed no significant differences. Conclusion: This study comprehensively evaluates the effects of simulated microgravity using a diverse panel of thyroid-related cell lines. These findings provide valuable insight into how microgravity could influence cancer biology, emphasizing the importance of further research on cancer behavior in space environments and its implications for human health during long-term space missions.

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

DOI: 10.32604/or.2025.065847

Authors: JONG-HYUK AHN, JIN WOOK YI

Institutions: Chung-Ang University Hospital, Inha University, Inha University Hospital

Language: English

Topic: Spaceflight effects on biology

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4411286448