Defining early vascular aging in youth: an expert consensus document from the youth vascular consortium
Year: 2025
Type: article
Abstract: The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, childhood and/or adolescence, structural and/or functional characteristics of the macrovascular and/or microvascular system may deviate from that expected for the chronological age of the individual. Assessing vascular aging from a young age may help detect and prevent the early onset of cardiovascular disease. This consensus document from the Youth Vascular Consortium outlines the principles of EVA in youth (birth to 24 years), examines factors influencing vascular growth, and identifies current knowledge gaps. It also provides an expert consensus on defining EVA in youth. Supplementary Tables 1-3, http://links.lww.com/HJH/C733 , http://links.lww.com/HJH/C734 , http://links.lww.com/HJH/C735 supply key references for risk factors associated with EVA at different points in development; 1. Neonates to childhood; 2. Adolescence; 3. Young adults. Supplementary Table 4, http://links.lww.com/HJH/C736 displays reference ranges of EVA in adults.
Source: Journal of Hypertension
Authors: Ruan Kruger, Jeanne Hersant, Vimarsha Kodithuwakku, Michél Strauss-Kruger, Manish D. Sinha, Madeleine Johansson, Mieczysław Litwin, Henner Hanssen, Karsten Königstein, Erzsébet V. Hidvégi, Lee Stoner, Keeron Stone, Christopher J.A. Pugh, Catharina M.C. Mels, Yolandi Breet, Wayne Smith, Daniel Bia, Yanina Zócalo, Alejandro Diaz, Anuradha Khadilkar, Vikas R. Dharnidharka, Giacomo Pucci, Elaine M. Urbina, Rosa-Maria Bruno, Peter M. Nilsson, Rachel E. Climie
Institutions: North-West University, University of Tasmania, Menzies Institute for Medical Research, Université d'Angers, King's College London, Guy's and St Thomas' NHS Foundation Trust, Evelina London Children's Healthcare, Lund University, Skåne University Hospital, Children's Memorial Health Institute, University of Basel, University of Szeged, University of Pecs, University of North Carolina at Chapel Hill, Cardiff Metropolitan University, Universidad de la República de Uruguay, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Centro de la Provincia de Buenos Aires, St. Louis Children's Hospital, Washington University in St. Louis, University of Perugia, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Inserm, Université Paris Cité, Paris Cardiovascular Research Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4411288582