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Electrochemical Oxidative [3 + 2] Annulation of p ‐Methoxy Anilines with Enaminones toward 3‐Acyl Indoles

Year: 2025

Type: article

Abstract: An electrochemical oxidative [3 + 2] annulation of p ‐methoxy anilines with enaminones is reported. This protocol enables facile synthesis of 3‐acyl indoles in moderate to good yields under mild conditions, featuring excellent functional group tolerance, operational simplicity, and gram‐scale scalability. Based on the cyclic voltammetry and control experiments, a plausible mechanism involving the aniline radical pathway is proposed.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.9597