Work

eAmidation: An Electrochemical Amidation of Aldehydes via the Oxidation of N ‐Aryl Hydrazones

Year: 2025

Type: article

Abstract: In recent years, the use of electrochemistry has emerged as a powerful yet sustainable means of enabling key transformations. Amidation is one of the most frequently executed transformations in synthetic chemistry, and using an electrochemical approach, the current study has demonstrated the synthesis of amides from aldehydes and amines. Mechanistic work indicates that the reaction proceeds via the oxidation of an intermediate hydrazone to generate an acyl diazene as the acylating species. The protocol developed has enabled the synthesis of a broad range of amides, including access to pharmaceutically relevant products, directly from aldehydes without recourse for hazardous chemical oxidants and activating agents.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.9587

Authors: Luke Chen, James David Francis Thompson, Craig Jamieson

Institution: University of Strathclyde

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funder: Engineering and Physical Sciences Research Council