Work

Palisaded Encapsulated (Solitary Circumscribed) Neuroma Affecting the Lip Aesthetics: Case Report and Literature Review

Year: 2025

Type: article

Abstract: Palisaded encapsulated (solitary circumscribed) neuroma (PEN) is a benign nerve sheath tumor, considered a reactive rather than a neoplastic lesion, predominantly found in the head and neck skin and oral mucosa. In the lip regions, less than 20 cases of PEN have been reported, and the differential diagnosis is a challenge. We present a 40-year-old male with a long-standing asymptomatic nodule on the lower lip, causing significant aesthetic discomfort, and a literature review of this tumor in the lips. After surgical excision, the histopathological analysis associated with immunohistochemical markers was essential for establishing the PEN diagnosis in the lower lip. Although rare, the PEN in the lip region can cause significant patient aesthetic discomfort, and histopathological analysis is crucial to distinguish this benign neural tumor from other long-standing lesions in the vermillion of the lips.

Source: Case Reports in Dentistry

DOI: 10.1155/crid/9705734

Authors: Kaique Alberto Preto, Gabriela Lopes-Santos, Cléverson Teixeira Soares, Ana Paula Moura Martins Delazari, Denise Tostes Oliveira

Institutions: Universidade de São Paulo, Instituto Lauro de Souza Lima

Language: English

Topic: Soft tissue tumors and treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $870