Year: 2025
Type: review
Abstract: The surgically challenging mouse orthotopic liver transplant model has provided numerous insights into liver immunobiology, cellular and molecular regulation of liver transplant ischemia-reperfusion injury, liver regeneration, the influence of major histocompatibility complex antigens on transplant outcome, spontaneous transplant tolerance, and regulation of allograft immunity. Nonarterialized and arterialized models have been established. Reduced-size liver transplant models have also been developed and used to determine critical mass and factors that determine tissue injury and regeneration. Since its first description 3 decades ago, the surgical demands of the model have limited its application to a relatively small number of centers focused on basic liver transplant research. Dissemination of and commitment to acquisition of the required technical skills will facilitate the application of cutting-edge experimental approaches to which the mouse model is well-suited and allow important key basic and translational questions in transplant immunology to be addressed.
Authors: Shinichiro Yokota, Wei Li, Pierre A. Clavien, Jerzy W. Kupiec-Weglinski, Angus W. Thomson
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
Awards: LIVER TRANSPLANTATION: THE ROLE OF DENDRITIC CELLS, TIM-3 Negative Costimulation Signaling at the Innate-Adaptive Immune interface in Liver Transplant Ischemia-Reperfusion Injury, Liver Antigen - Presenting Cells in Hepatic Injury and Transplantation, Regulation of Liver DC Function and Transplant Tolerance, Plasmacytoid Dendritic Cells and Transplant Tolerance, Innate-Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury, HuR/HIF – SIRT1 Signaling Axis in Liver Transplant Rejuvenation
OpenAlex ID: W4411298149