Work

Click-Triggered Bioorthogonal Bond-Cleavage Reactions

Year: 2025

Type: article

Abstract: Bioorthogonal bond-cleavage reactions have evolved into powerful tools for chemical biology, representing a promising strategy for achieving controlled release of molecules under physiologically relevant conditions, even in living organisms. Since their discovery, significant efforts have been invested in the development and understanding of the underlying chemistries to enhance the click-to-release performance, biocompatibility, and stability of bioorthogonal tools. In this review, we aim to provide a concise overview of click-triggered bioorthogonal bond-cleavage reactions, with an emphasis on the mechanisms and characteristics of the most commonly applied click-to-release chemistries.

Source: Topics in Current Chemistry

DOI: 10.1007/s41061-025-00492-1

Authors: Patrick Keppel, Sebastian Hecko, Hannes Mikula

Institution: TU Wien

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,590

Funders: Technische Universität Wien, European Research Council, HORIZON EUROPE European Innovation Council