Surgery with leukocyte and platelet-rich fibrin (L-PRF) vs. surgery alone for medication-related osteonecrosis of the jaw: A randomized controlled trial
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Multiple studies have reported high resolution rates of medication-related osteonecrosis of the jaw (MRONJ) with surgical treatment combined with platelet concentrates.However, no randomized controlled trials have been published to date comparing surgery combined with L-PRF to surgery alone.Material and Methods: We conducted a multicenter, open-label, parallel-group, randomized controlled trial to assess the effect of leukocyte-and platelet-rich fibrin (L-PRF) as an adjunct to surgery for the treatment MRONJ.Patients were randomly assigned to either surgery combined with L-PRF or surgery alone.The primary outcome was the proportion of patients achieving complete resolution of MRONJ lesions six months postoperatively.Complete resolution rates were compared using the chi-square (X²) test, and relative risk (RR) with 95% confidence intervals (CI) was calculated.Secondarily, we evaluated baseline quality of life using the EQ-5D-3L questionnaire and assessed the impact of L-PRF on quality-of-life measures.Results: A total of 41 participants were included in the study.Nineteen participants underwent surgery with L-PRF, while 22 underwent surgery alone.At the six-month follow-up, complete resolution was observed in 92% (11/12) of patients in the experimental group and 83% (15/18) in the control group (RR 1.1, 95% CI 0.84-1.43,p=0.51).The most affected domains in the baseline quality-of-life assessment were anxiety/depression and pain/discomfort.No statistically significant differences were observed between groups in any quality-of-life domain at six months.Conclusions: Our findings suggest that the use of L-PRF as an adjunct to surgery does not provide a significant clinical benefit compared to surgery alone.
DOI: 10.4317/jced.62824
Authors: EA. Ramos, JM. Muiño, M. Diamante, A. Echagüe, SA. Puia, D. Caruso
Language: English
Topic: Bone health and treatments
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411313748