Work

Chondrocyte-mimetic therapeutic microcarriers for synergistic chemo-mechanical signaling in cartilage regeneration

Year: 2025

Type: article

Abstract: the Rho/ROCK-actin-YAP axis. Furthermore, the chondrocyte-derived exosomes restore cartilage homeostasis by delivering chondrogenic miRNAs and regulating key metabolic processes, including lipid metabolism and ECM remodeling. Together, these therapeutic components play a synergistic role in driving chemo-mechanical signaling, promoting chondrocyte recruitment, proliferation, and maturation, ultimately coordinating cartilage repair. This biomimetic approach offers a promising strategy for cell-free cartilage regenerative therapies.

Source: Materials Horizons

DOI: 10.1039/d5mh00593k