Work

Multi-parametric functional optical spectroscopy to monitor the metabolic and vascular changes in small head and neck tumors in vivo with radiation stress

Year: 2025

Type: article

Abstract: We demonstrated a portable multi-parametric functional optical spectroscopy to monitor metabolic and vascular changes in small head and neck tumors in vivo with fractional radiation therapy. For the first time, we captured the key metabolic and vascular parameters of head and neck xenograft tumors in vivo prior to and post a total of 10 Gy fractional radiation therapy. Our animal studies showed dramatic vascular and metabolic changes in radioresistant head and neck tumors (rSCC-61) under radiation stress but not in radiosensitive head and neck tumors (SCC-61). Specifically, our data showed that rSCC-61 tumors had increased tissue oxygen saturation (indicating reoxygenation), increased total hemoglobin content (indicating blood perfusion), and increased oxygenated hemoglobin (indicating oxygen supply) post radiation therapy. Our study also showed that rSCC-61 tumors had decreased glucose uptake and increased mitochondrial function post-radiation therapy. In contrast, SCC-61 tumors had minimal changes in either vascular or metabolic parameters post-radiation treatment. These results demonstrated the potential of our portable multi-parametric functional optical spectroscopy to evaluate tumor vascular and metabolic changes under therapeutic stresses for future head and neck cancer research.

Source: Biomedical Optics Express

DOI: 10.1364/boe.565339

Authors: Jing Yan, Pranto Soumik Saha, Md Zahid Hasan, Cristina M. Furdui, Caigang Zhu

Institutions: University of Kentucky, Wake Forest University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,913