Impact of breast cancer history on decision-making for ovarian cancer risk-reducing surgery in the TUBA-WISP-II study
Year: 2025
Type: article
Abstract: BACKGROUND: Female BRCA1/2 pathogenic variant carriers have an increased risk of breast and ovarian cancer. In the TUBA-WISP II study, women chose between standard risk-reducing salpingo-oophorectomy and risk-reducing salpingectomy with delayed oophorectomy to prevent ovarian cancer. At inclusion, a substantial proportion of the enrolled women had a history of breast cancer, which could affect decision-making. OBJECTIVE: This study aimed to describe decision-making regarding the type and timing of risk-reducing surgery between women with and without a history of breast cancer. STUDY DESIGN: Premenopausal BRCA1/2 pathogenic variant carriers completed Web-based questionnaires on their personal histories and preferred risk-reducing strategy. Differences in the type and timing of the first risk-reducing surgery between women with and without a history of breast cancer were assessed. A multivariate analysis was performed to examine personal, environmental, and breast cancer-related characteristics associated with the choice of risk-reducing salpingo-oophorectomy among women with a history of breast cancer. RESULTS: This study included 1676 women, among whom 222 (13.2%) had a history of breast cancer. Of note, 77.0% of women with a history of breast cancer chose risk-reducing salpingectomy with delayed oophorectomy compared with 78.0% of women without a history of breast cancer (P=.73). Individuals with breast cancer before their BRCA1/2 diagnosis had their first surgery at a median of 2 years later than those who were diagnosed simultaneously or had their BRCA1/2 diagnosis first. Women diagnosed with breast cancer within the guideline age range for completing risk-reducing salpingo-oophorectomy (35-40 years for BRCA1 and 40-45 years for BRCA2) more often chose risk-reducing salpingo-oophorectomy than those before the guideline age range (odds ratio, 6.2 [95% confidence interval, 1.9-19.9]). CONCLUSION: A history of breast cancer was not associated with a preference for a specific risk-reducing strategy. Women diagnosed with breast cancer within the guideline age range more often chose risk-reducing salpingo-oophorectomy than those diagnosed with breast cancer before the guideline age range.
Authors: Tamar A. Gootzen, Miranda P. Steenbeek, Marleen M.H.J. van Gelder, Majke H.D. van Bommel, Anja J. N.H. Timmer-Bonte, C. Marleen Kets, Roni Nitecki-Wilke, Elizabeth M. Swisher, Barbara M. Norquist, Karen H. Lu, Rosella P.M.G. Hermens, Joanne A. de Hullu, Marjan L. Knippenberg, Mirjam J.A. Apperloo, Jamie Bakkum-Gamez, Glauco Baiocchi Neto, Monika Bojdys-Szyndlar, Stephanie Blank, Monique M.A. Brood-van Zanten, Sjors F.P.J. Coppus, Anne Dørum, H.C. van Doorn, Colleen Feltmate, Angelique Flöter Rådestad, Maxime Fastrez, Robert Fruscio, Katja N. Gaarenstroom, Andrea Hagemann, Ala Jabri Haug, Martha Hickey, Janneke S. Hoogstad-van Evert, Susanne Housmans, Sarah Kim, Arnold-Jan Kruse, Kara Long Roche, Claudia Marchetti, Marian J.E. Mourits, Orla McNally, Michaela Onstad-Grinsfelder, Elisabeth Berge Nilsen, Krzysztof Nowosielski, Eva-Maria Roes, Angelique Flöter Rådestad, Nathalie Reesink-Peeters, Agnieszka Rychlik, Santiago Scasso Caravia, Brigitte F.M. Slangen, Elisa Sieghartsleitner, Maciej Stukan, Anna M. Perrone, M. Caroline Vos, Refika Yigit, Ronald P. Zweemer
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,410
OpenAlex ID: W4411327355