Dual Photoredox/Cu‐Catalysis Enables Diastereoselective Synthesis of 3‐β‐Ethynyltropanes via Decarboxylative Alkynylation
Year: 2025
Type: article
Abstract: An efficient decarboxylative alkynylation of a tropane redox‐active ester with terminal alkynes is described, yielding ethynyltropanes with exclusive β‐configuration. This cost‐effective process utilizes mild, nontoxic copper‐catalyzed, photoinduced reaction conditions. Beyond introducing a novel pathway for the catalytic alkynylation of nortropanes, this method offers a versatile and convergent approach for synthesizing complex nortropane derivatives through further functionalization of the triple bond, including reductions, and inverse demand Diels–Alder reactions.
Source: Advanced Synthesis & Catalysis
Institutions: Centre National de la Recherche Scientifique, École Polytechnique, École Nationale Supérieure de Techniques Avancées, Université Paris-Saclay, Laboratoire de Synthèse Organique, Biomolécules : Conception, Isolement, Synthèse, Institut de Chimie des Substances Naturelles, University of Monastir, Institut de Chimie Moléculaire et des Matériaux d'Orsay
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,650
Awards: G333703559, G6020365638, G969381615
OpenAlex ID: W4411328299