The role of high-density lipoprotein and Vitamin D in exercise-induced neuroprotection in epileptic rats
Year: 2025
Type: article
Abstract: Previous studies have reported the neuroprotective effects of exercise in epilepsy. Hence, this study aimed to investigate the potential mechanisms underlying these neuroprotective effects by examining changes in high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Vitamin D levels. Wistar rats were divided into four groups: sham, pentylenetetrazole (PTZ), exercise (EX), and PTZ + EX. Seizures were induced in the PTZ and PTZ + EX groups through intraperitoneal administration of PTZ (35 mg/kg) every other day for 1 month. The EX and PTZ + EX groups underwent daily exercise sessions (30 min/session) for 1 month. Serum levels of Vitamin D, HDL, and LDL were measured, and neuronal damage was assessed in the hippocampus and somatosensory cortex. The PTZ + EX group showed a significant increase in serum HDL and Vitamin D levels compared to the PTZ group. Histological analysis revealed a significant increase in neuronal damage in the PTZ group compared to the sham group. In contrast, both PTZ + EX and EX groups demonstrated a reduction in neuronal damage compared to the PTZ group. These findings suggest that HDL and Vitamin D may contribute to the neuroprotective benefits of exercise. Furthermore, exercise could potentially serve as a complementary strategy to counteract Vitamin D and HDL deficiencies associated with long-term antiepileptic drug use.
Source: Advanced Neurology
DOI: 10.36922/an.8347
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411333293