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Malignant transformation of pituitary adenoma to carcinosarcoma: illustrative case

Year: 2025

Type: article

Abstract: BACKGROUND: Carcinosarcomatous transformation is a rare complication following radiotherapy for pituitary adenomas (PAs). OBSERVATIONS: The authors report what they believe to be the first case of a benign nonfunctioning PA developing into a carcinosarcoma after surgery and radiotherapy. LESSONS: Radiotherapy for PAs should account for the risk of secondary intracranial tumors, with long-term follow-up recommended for treated patients. Combined therapeutic strategies may be considered for radiation-induced sarcomas, and comprehensive molecular pathological studies of radiation-induced tumors are imperative for advancing understanding and management. https://thejns.org/doi/10.3171/CASE24765.

Source: Journal of Neurosurgery Case Lessons

DOI: 10.3171/case24765

Authors: Lin Shaoyong, Huanxiang Huang, Mingyue Wang, Jun Li, Yuhui Chen, Shousen Wang

Institutions: Fujian Medical University, Xiamen University

Language: English

Topic: Pituitary Gland Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4411333700

FWCI:

Cites: 15

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Related to: 10