Year: 2025
Type: article
Study design: Case Report
Abstract: A 12-year-old castrated male Labrador Retriever presented with asymptomatic hypercalcemia. Based on elevated parathyroid hormone levels and an enlarged parathyroid gland, primary hyperparathyroidism was suspected, and parathyroidectomy was performed, but the hypercalcemia did not improve. Histopathology of three resected parathyroid glands revealed hyperplasia and hypertrophy of the principal cells. After surgery, the fractional excretion of calcium examined in a spot urine sample was close to that in healthy dogs, but lower than that in a dog with primary hyperparathyroidism. Autoantibodies against calcium-sensing receptor (CaSR) were confirmed by incubating a cell line expressing canine CaSR with a serum sample from the hypercalcemic dog. Our report is the first to describe the diagnosis of acquired hypocalciuric hypercalcemia in a dog.
DOI: 10.1292/jvms.25-0112
Authors: Takahiro TESHIMA, Tomokazu NAGASHIMA, Yuyo YASUMURA, Akiko YASUDA, Yuichi MIYAGAWA, Masaki MICHISHITA, Ryohei SUZUKI, Hirotaka MATSUMOTO
Institution: Nippon Veterinary and Life Science University
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411335243