Work

Decidual macrophages as therapeutic targets in preterm labour

Year: 2025

Type: article

Abstract: The initiation of labour in humans remains poorly understood, although there is mounting evidence for a role for decidual macrophages. These may trigger labour by promoting a proinflammatory state, thereby modulating progesterone signalling and weakening fetal membranes. Preclinical work targeting macrophages therapeutically shows promise in preventing preterm labour, underscoring their significance in this process.

Source: Trends in Molecular Medicine

DOI: 10.1016/j.molmed.2025.05.013

Authors: Emilie O. Paterson, Daniel J. Short, Victoria Male

Institution: Imperial College London

Language: English

Topic: Preterm Birth and Chorioamnionitis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030