Administration of high-dose intravenous vitamin C in healthy dogs transiently leads to a false increase in portable blood glucose monitor and interstitial glucose monitor readings
Year: 2025
Type: article
Abstract: Objective: To investigate the effects of high-dose IV vitamin C (HDIVC) on handheld portable blood glucose monitor (PBGM) and interstitial glucose monitor (IGM) readings in dogs. Methods: 6 client-owned Border Collies with normal physical examinations and baseline bloodwork were enrolled in this prospective experimental study from November through December 2024. Glucose was measured via an IGM, PBGM, and laboratory blood glucose analyzer (LG) at time (T)-0, T1, T2, T3, T6, T12, T18, and T24 hours after HDIVC (200 mg/kg; ascorbic acid 500 mg/mL diluted 1:10 with sterile water, given over 30 minutes, IV). Results: The median PBGM (T1, 189 mg/dL; T2, 138 mg/dL) and IGM (T1, high; T2, 321 mg/dL) readings were significantly higher than LG (T1, 76.5 mg/dL; T2, 93.5 mg/dL) at T1 and T2. The median IGM (183 mg/dL) readings were significantly higher than LG (99 mg/dL) at T3. There was no significant difference between modalities at T0 nor from T6 on. On consensus error grid analysis, all PBGM readings at T1 and 1 of 6 readings at T2 were clinically unacceptable. All IGM readings at T1 and T2 and 2 of 6 readings at T3 were clinically unacceptable. Conclusions: A 200-mg/kg, IV, bolus of vitamin C in healthy dogs causes clinically significant elevations in PBGM and IGM glucose readings that normalize within 3 and 6 hours, respectively. Clinical Relevance: Avoid the use of PBGM and IGM until 3 and 6 hours, respectively, after HDIVC in healthy dogs.
Authors: Joanna Lum, Angie Andrea Rincon, Elizabeth J. Thomovsky, Paula A. Johnson, Aimee C. Brooks, Hsin-Yi Weng
Institution: Purdue University West Lafayette
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411336389