Work

Early outcome-prediction with an automated EEG background trend in hypothermia-treated newborns with encephalopathy

Year: 2025

Type: article

Abstract: BACKGROUND: Therapeutic hypothermia is an intervention that improves outcomes and alters early outcome-prediction in infants with moderate-severe hypoxic-ischemic encephalopathy (HIE). This study evaluated the early predictive accuracy of a fully automated continuous EEG background trend, Brain State of the Newborn (BSN) in a regional Swedish cohort of infants with presumed HIE. METHOD: The BSN trend characterizes 1-min segments of EEG from zero (inactive) to 100 (continuous) and was generated from aEEG/EEG in 85 infants treated with hypothermia. BSN trajectories were compared in relation to clinical grading of encephalopathy and outcome. Receiver operating characteristics were computed for good (no/mild impairment) and poor outcomes (moderate/severe impairment or death). RESULTS: During the first 48 h, BSN levels differed significantly between moderate and severe HIE (typical median BSN levels >80 and <40, respectively). The predictive accuracy of BSN was high already at 6 h (AUC 0.84) and at 12 h (AUC 0.91), with corresponding positive predictive values (PPV) > 0.92 for good outcome (cutoff BSN > 80) and PPV > 0.95 for poor outcome (cutoff BSN < 40). CONCLUSION: BSN gives a continuous and objective measure of EEG background activity, which is highly predictive of good and poor outcomes already from the first 6-12 h in hypothermia-treated infants with moderate-severe HIE. IMPACT: Brain State of the Newborn (BSN) is a deep learning-based EEG trend displaying electrocortical activity as numerical values. Here we establish that BSN trends over the first 48 h differ between infants with moderate versus severe hypoxic-ischemic encephalopathy (HIE) and is highly predictive of long-term outcome. This is the first study applying BSN trends in a cohort of exclusively hypothermia-treated infants, demonstrating its value for outcome-prediction already from the first 12 h after birth. The BSN provides a continuous bedside evaluation of brain function that complements the visual aEEG/EEG review and can assist bedside assessments in neonatal intensive care units.

Source: Pediatric Research

DOI: 10.1038/s41390-025-04193-9

Authors: Karla Gonzalez-Tamez, Saeed Montazeri, Johan Ågren, Sampsa Vanhatalo, Lena Hellström-Westas

Institutions: Uppsala University, University of Helsinki

Language: English

Topic: Neonatal and fetal brain pathology

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,390