Work

DNA-triggered activation of aptamer-neutralized enzyme for in situ formation of injectable hydrogel

Year: 2025

Type: article

Abstract: aneurysm and endovascular embolization were further conducted, and the results showed the DNA administered out of the hydrogel system could trigger the activation of aptamer-bound enzymes for the accelerated formation of the injectable hydrogel. Therefore, this study has successfully demonstrated that a bispecific aptamer-neutralized enzyme in the pre-gelation system can be rapidly released to accelerate the formation of injectable hydrogels when the system is in contact with the blood that contains a triggering DNA.

Source: Nanoscale Horizons

DOI: 10.1039/d5nh00314h

Authors: Connie Wen, Yixun Wang, Yixun Wang, Kyungsene Lee, Xuelin Wang, Yong Wang, Yong Wang

Institution: Pennsylvania State University

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: G1762464398, G3093955063, Non-covalent functionalization of collagen for growth factor delivery using bispecific aptamers, G5903664271, Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel, G9000270200

OpenAlex ID: W4411344971

FWCI: 0.235

Cites: 44

Cited by: 1

Related to: 10