Work

CircSPINT2 confers sensitivity to osimertinib via hsa-miR-1296-3p/RBP1 axis and inhibits NSCLC progression

Year: 2025

Type: article

Abstract: findings. Conclusively, our study demonstrates that circSPINT2 possesses tumor-suppressive functions; the restoration of circSPINT2 expression level confers sensitivity to osimertinib treatment via miR-1296-3p/RBP1 axis. The secreted circSPINT2 may serve as a monitoring biomarker for osimertinib resistance status in LUAD.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2025.201007

Authors: Nalini Devi Verusingam, Aliaksandr A. Yarmishyn, Min-Long Tsai, Ping-Hsing Tsai, Yi-Chen Chen, Chih-Ling Yeh, Soon-Keng Cheong, Po-Kuei Hsu, Shih-Hwa Chiou, Alan Han-Kiat Ong, Mong-Lien Wang

Institutions: National Yang Ming Chiao Tung University, Taipei Veterans General Hospital, National Cancer Council Malaysia, Universiti Tunku Abdul Rahman, Genomics Research Center, Academia Sinica, Academia Sinica

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: National Science and Technology Council, Ministry of Education, Veterans Affairs Council, R.O.C., Universiti Tunku Abdul Rahman, Ministry of Science and Technology, Taiwan, Taipei Veterans General Hospital, National Yang Ming Chiao Tung University

Awards: G1129907598, G2276806434, G2374737230, G2510751261, G326466802, G4405799950, G5738191406, G5943091298, G6614628453, G6853734866, Dissecting the Roles and Underlying Mechanisms of Nkx2.1 in Controlling Lung Cancer Drug Resistance and Shaping Tumor Microenvironment, G698387848, G7302398467, G989561909

OpenAlex ID: W4411350291

FWCI: 1.26

Cites: 81

Cited by: 5

Related to: 10