Supplemental Figure 1 from Spatial Profiling Identifies Regionally Distinct Microenvironments and Targetable Immunosuppressive Mechanisms in Pediatric Osteosarcoma Pulmonary Metastases
Year: 2025
Type: supplementary-materials
Abstract: Distribution and abundance of genes encoding functional and phenotypic macrophage markers. Clustered dot plots illustrating the spatial distribution of gene encoding different functional and phenotypic macrophage markers within each individual metastatic osteosarcoma specimen. The color bar above each dot plot corresponds to the different spatial clusters displayed on the adjoining spatial cluster maps that are shown for reference (above). Separate color palettes denote the independent clustering analysis of each specimen. Spatial clusters were localized to the extratumoral (black) or intratumoral (gray) microenvironments as depicted in the second color bar.
Authors: Jason Eigenbrood, Nathan Wong, Paul Mallory, Janice S. Pereira, Demond Williams, Douglass W. Morris-II, Jessica A. Beck, James C. Cronk, Carly M. Sayers, Monica Mendez, Linus Kaiser, Julie Galindo, Jatinder Singh, Ashley Cardamone, Milind Pore, Michael Kelly, Amy K. LeBlanc, Jennifer Cotter, Rosandra N. Kaplan, Troy A. McEachron
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4411355837