Ultrasensitive Quantification of Thyroid-Stimulating Hormone and Thyroxine by Nanoelectronic SnS2 Transistor Sensors
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide The measurement of thyroid hormones in serum is widely regarded as the most valuable single laboratory tool for assessing thyroid function. This study presents a highly sensitive tin disulfide nanosheet-fabricated field-effect transistor (SnS 2 -FET) designed for the detections of human thyroid-stimulating hormone (hTSH) and thyroxine (T4). By co-modifying an antibody (Ab TSH for detecting hTSH), or a DNA aptamer (Apt T4 for detecting T4), with polyethylene glycol (PEG) on the SnS 2 -FET channel surface, the PEG:Ab TSH /SnS 2 -FET and PEG:Apt T4 /SnS 2 -FET devices achieve highly sensitive and selective detections of hTSH and T4, respectively, even in a high ionic strength buffer (1× PBS) or undiluted serum. With a low limit of detection (in the femtomolar level) and a wide linear working range (spanning at least 6 orders of magnitude of analyte concentration), the PEG:Ab TSH /SnS 2 -FET immunosensor and PEG:Apt T4 /SnS 2 -FET aptasensor can detect the hTSH and T4 levels encountered in the spectrum of thyroid disorders. Notably, these specific receptor-modified SnS 2 -FET devices display negligible cross-reactivity with other pituitary hormones or serum components. This research indicates that the nanoelectronic SnS 2 -FET sensor platforms hold significant potential for point-of-care clinical diagnostics, particularly for the ultrasensitive detection and early screening of medical conditions.
Source: ACS Sensors
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W4411360692