Year: 2025
Type: article
Abstract: OBJECTIVE: The severe insulin-resistant diabetes (SIRD) endotype is associated with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD. RESEARCH DESIGN AND METHODS: Participants (N = 420) of the German Diabetes Study (GDS) were assigned to diabetes clusters using a validated algorithm. 1H-magnetic resonance methods were used to quantify intramyocellular lipids (IMCLs), intrahepatic lipids (IHLs), and visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes. RESULTS: Aside from elevated IHLs (P < 0.01), SIRD showed higher VAT and SAT than other endotypes after adjustment for BMI (all P < 0.05) but not for multiple comparisons. All endotypes featured comparable IMCLs. VAT volume and IHLs correlated with cardiovascular risk scores (Framingham r = 0.661 and 0.548, respectively, P < 0.05). Polygenic risk scores for VAT were associated with higher cardiovascular risk. CONCLUSIONS: SIRD features higher IHLs and nominally higher VAT volume, which likely contribute to increased cardiovascular risk, highlighting implications for tailored prevention and treatment.
Source: Diabetes Care
DOI: 10.2337/dc24-2023
Authors: Oana-Patricia Zaharia, Yuliya Kupriyanova, Pavel Bobrov, Christian Binsch, Birgit Knebel, Tim Mori, Iryna Yurchenko, Dania Marel Mendez Cardenas, Theresa Kössler, Nina Trinks, Martin Schön, Kálmán B. Bódis, Robert Wagner, Vera Schrauwen-Hinderling, Michael Roden, GDS Group*, Michael Roden, Hadi Al-Hasani, Bengt F. Belgardt, Gidon J. Bönhof, Gerd Geerling, Christian Herder, Andrea Icks, Karin Jandeleit-Dahm, Oliver Kuss, Eckhard Lammert, Sabrina Schlesinger, V. Schrauwen-Hinderling, Julia Szendroedi, Sandra Trenkamp, Robert Wagner
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4411366178