Nanoconfinement in a Supramolecular Capsule Promotes the Formation of 5- to 8-Membered Rings in Cycloalkane-[b]-indoles
Year: 2025
Type: article
Abstract: Challenging cyclization of common- to medium-sized rings is promoted by nanoconfinement inside the cavity of a self-assembled hexameric resorcinarene capsule. While no cyclization occurs outside the capsule, high to excellent yields of cycloalkane-[b]-indoles are obtained inside the capsule irrespective of ring size (5-8 members). Kinetic analysis coupled to NMR investigation of substrate binding shows that the cyclization step under nanoconfinement is not rate-determining, not even for the formation of an 8-membered ring.
Source: Organic Letters
Authors: Emanuele Spatola, Roberta Cacciapaglia, Federico Frateloreto, Alessandra Procopio, Fausta Giannetti, Lorenzo Napoli, Martina De Angelis, Stefano Di Stefano, Giorgio Olivo
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G1406644497, G4372321045, G8469396528
OpenAlex ID: W4411367638