Work

Azadirachta indica leaf extract: Phytochemical composition and antioxidant, antibacterial, and antifungal activities

Year: 2025

Type: article

Abstract: The chemical components and natural traits of Azadirachta indica A. Juss. leaf extract from arid environments has been studied. LC-MS analysis identified quercetin, oleanolic acid, salicin, and catechin among the many bioactive compounds in the sample. It was observed that at a concentration of 25.01 ± 0.71 µg/mL, DPPH exhibited antioxidant activity with an IC50 value that is higher than that of β-carotene bleaching (22.29 ± 0.66 µg/mL), ABTS assay (45.09 ± 1.23 µg/mL), respectively. Bacillussubtilis, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa showed susceptibility to the extract, with MICs ranging from VHC to 30 mg/mL while Alternaria sp., Fusarium solani, and Thielaviopsis paradox represent the fungal strains tested for their sensitivity to this extract. Therefore, Azadirachta indica leaf extract from dry regions exhibits significant effects, potentially explaining its traditional use in medicine and agriculture.

Source: International Journal of Secondary Metabolite

DOI: 10.21448/ijsm.1511401

Authors: Abadi Abderrezzak, Wassima Lakhdari, Salah Neghmouche Nacer, Abderrahmene Dehliz, Hafida Khelafi, Ridha Ben Salem, Moussaoui Younes

Institutions: University of Eloued, Institut National de la Recherche Agronomique d'Algérie, University of Boumerdes, University of Sfax, University of Gafsa

Language: English

Topic: Essential Oils and Antimicrobial Activity

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411368900

FWCI: 0.879

Cites: 46

Cited by: 2

Related to: 10