Work

Drug-Induced Dysphagia and Diarrhea: A Case of Colchicine Toxicity

Year: 2025

Type: article

Abstract: We report a 70-year-old woman with 1 year of progressive diarrhea, dysphagia, and 100-pound weight loss, resulting in severe protein-calorie malnutrition. Endoscopy revealed mid-esophageal webs, erosions, erythema, gastric antrum and duodenum congestion, and mucosal granularity in the sigmoid colon. Biopsies from the esophagus, duodenum, and colon showed ring mitoses, prominent dyskeratosis/apoptosis, epithelial atypia, and regenerative changes consistent with colchicine toxicity. Her symptoms resolved within 3 days of discontinuing colchicine.

Source: Gastro Hep Advances

DOI: 10.1016/j.gastha.2025.100726

Authors: Meredith Yellen, Rangesh Modi, Rebecca Yao, Tanner Storozuk, Kevin Tanager, Kg Reddy

Institutions: University of Chicago, University of Chicago Medical Center

Language: English

Topic: Esophageal and GI Pathology

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000