Work

Leukocyte Adhesion Defect Type I: Delayed Umbilical Cord Separation, a Surplus of Cells, and a Deficit of Defense

Year: 2025

Type: article

Abstract: A 3-month-old male infant presented with fever and irritability. He had a history of delayed umbilical cord separation (detachment on day 28) and had previously been evaluated for umbilical granuloma and malodorous discharge (Figures 1A, B). At age two months, while abroad, he was hospitalized for umbilical stump bleeding. Labs showed elevated C-reactive protein (CRP, 8.5 mg/dL), erythrocyte sedimentation rate (ESR, 48 mm/hour), and leukocytosis (white blood cells [WBC] 28,500/mcL). At that time, leukemia was excluded via peripheral smear and bone marrow aspirate.

Source: The Journal of Pediatrics

DOI: 10.1016/j.jpeds.2025.114688

Authors: Mona-Lisa Weinberger, Birgit Stark, Barbara Winkler, Dmitry Evseev, Milen Minkov

Institutions: Johannes Kepler University of Linz, Kepler Universitätsklinikum, Sigmund Freud Privatuniversität Wien

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,570