Nanorobot-Cell Communication via In Situ Generation of Biochemical Signals: Toward Regenerative Therapies
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Achieving precise control of cellular processes drives possibilities for next-generation therapeutic approaches. However, existing technologies for influencing cell behavior primarily rely on specific drug delivery, limiting their ability to mimic natural cellular communication processes. In this work, we developed glucose-powered gold-silica (Au-SiO 2 ) nanorobots that induce cell migration by generating steady-state hydrogen peroxide (H 2 O 2 ) as a biochemical signaling molecule to mimic natural cellular communication with high spatial resolution. These nanorobots leverage the unique 2-in-1 catalytic activity of gold nanoparticles for glucose oxidation and H 2 O 2 decomposition, allowing for precise control over the generation of steady-state H 2 O 2 concentration and enhanced diffusion powered by glucose within the cellular microenvironment. We further demonstrated that at low dosages of nanorobots, the steady-state H 2 O 2 generation promotes cell migration and proliferation, while higher dosages of nanorobots slow down cell proliferation. The proposed design of this biocompatible nanorobot is intended to enable communication with the environment and provide a noninvasive, biochemical command system for regulating cellular behavior. Additionally, we show proof of principle of a method by which nanorobots can augment wound healing and similar regenerative therapies.
Source: ACS Nano
Authors: Roshan Velluvakandy, Xiaohui Ju, Martin Pumera
Language: English
Topic: Micro and Nano Robotics
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: G1153767801, G1413419130, G1454965787, G2207473264, National Infrastructure for Biological and Medical Imaging, G2457326474, G2677629327, G2678520069, Research infrastructure CzechNanoLab, G291036901, G3076994783, G3735356012, G5162580495, G5287318854, G6174040907, G6358972985, G715263156, G7615078301, Smart micro- and nanorobots for water purification, G8140083606
OpenAlex ID: W4411372399