Work

Specialized response of default mode subnetworks and multiple-demand regions to changes in social content, place and time

Year: 2025

Type: article

Abstract: This study used functional MRI data from the StudyForrest dataset to investigate the role of subnetworks of the default mode network (DMN) during naturalistic stimulus transitions of different types and magnitudes. We found distinct activation profiles within the DMN: the dmPFC subnetwork was specifically associated with social and location transitions, the MTL subnetwork preferred location and temporal transitions, while the Core DMN subnetwork responded to all three transition types. The multiple-demand network instead responded selectively to temporal transitions. These distinct response profiles appeared largely invariant to the semantic distance implied by the transitions. All subnetworks also responded significantly, and in a graded manner, to subjective event boundaries. Results suggest specific roles of the DMN subnetworks in perceiving and segmenting naturalistic events, supporting the view that DMN subnetworks cooperate in interpreting continuous external events and maintaining an updated contextual model of the world.

Source: Neuropsychologia

DOI: 10.1016/j.neuropsychologia.2025.109206

Authors: Ashley X. Zhou, Reza Rajimehr, Arsalan Firoozi, John Duncan, Daniel J. Mitchell

Institutions: MRC Cognition and Brain Sciences Unit, University of Cambridge, Institute for Research in Fundamental Sciences, Sharif University of Technology

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,300