Efecto hepatoprotector de la almendra de semilla Cucurbita maxima (zapallo macre) frente a la toxicidad con paracetamol en ratas
Year: 2025
Type: article
Abstract: Objectives: The present study aims to determine the hepatoprotective effect of Cucúrbita máxima seed kernel suspension in rats subjected to treatment with paracetamol. Materials and methods: analytical, experimental, cross-sectional and prospective type of study; 48 adult male Holtzman rats of 2 months of age, weighing 225 ± 24.7g were used. The seed kernels of Cucurbita maxima (pumpkin macre) were used, which was obtained by removing the episperm and cuticle that surrounds the endosperm of the seed, obtaining the pumpkin kernel, which was crushed in a mortar and suspended in distilled water. The rats were randomly distributed into six groups (n=8). They received the following treatments for ten days, via peroral route: groups I and II: physiological saline 10mL/kg; group III: silymarin 100mg/kg; group IV: 50mg/kg; group V: 300mg/kg and group VI: 800mg/kg of seed kernel suspension, Cucurbita maxima. On the sixth day of treatment, groups II to VI received paracetamol at 400mg/kg peroral, one hour apart from the previous treatment, until completing the ten days. Results: Cucurbita maxima seed kernel suspension exerted a hepatoprotective effect, as evidenced by enzymatic indicators (ALT and AST), albumin, total proteins and TBARS in liver; and histopathologically showed a restoration of paracetamol-induced lesions. Conclusions: Cucurbita maxima (zapallo macre) seed kernel exerts a hepatoprotective effect.
Authors: José Antonio Benjamin Caballero Calampa, Cesar Adolfo Flores Valle, Oscar Gabriel Pajuelo Ríos, Grace Yanella Cabrejos Silva, Oscar Gustavo Huamán Gutiérrez
Institution: National University of San Marcos
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4411373444