Amino Acid Derived Hydrogen Bond Donor (HBD) Catalyst for the Synthesis of Cyclic Carbonates and Cyclic Dithiocarbonates: Experimental and Computational Studies
Year: 2025
Type: article
Abstract: Amino acid derived functionalized compounds have been designed, synthesized, and utilized as hydrogen bond donor (HBD) catalysts for the successful installation of CO 2 and CS 2 in epoxide for the synthesis of corresponding cyclic carbonates and dithiocarbonates. Here, the structural features of the catalysts play pivotal role for the viable utilization of the C‐1 synthons. The rational design of the HBD catalysts involved strategic derivatization of the amine group of the amino acid ester to cater suitable noncovalent interactions with the substrate epoxide. Suitable hydrogen bonding interactions take place between the purposefully incorporated phenolic −OH groups present in the catalysts and the “O” atom of the epoxide. The syntheses of such amino acid derivatives involve sequential functional group modifications with expedient reaction steps. The catalytic activity of such novel amino acid ester derivatives was studied for CO 2 and CS 2 installation reactions with various epoxides. Excellent results were obtained in terms of selectivity and yield of the final products. Tetra‐butyl ammonium iodide (TBAI) was used as a cocatalyst and the reactions were optimized in a very mild and solvent free condition. Overall, this research work demonstrates effective implementation of newly developed HBD catalysts in the one‐pot, multi‐steps domino reaction protocol.
Authors: Supratim Halder, Supratim Halder, Koushik Das, Saumik Sen, Sandipan Halder, Sandipan Halder
Language: English
Subfield: Process Chemistry and Technology
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: green
Awards: G1784655173, G5934308626
OpenAlex ID: W4411375195