Year: 2025
Type: article
Abstract: This review focuses on bioinspired semi-hemic iron (III) complexes as innovative catalysts for chemical and photochemical Oxygen Atom Transfer (OAT) reactions.Endosulfatases, particularly HSulf1 and HSulf2, play critical roles in regulating Heparan Sulfate (HS) sulfation, influencing various biological processes and disease mechanisms, including cancer and inflammation.We examine the synthesis and characterization of novel dipyrrin-based iron complexes, which stabilize high-valent iron-oxo intermediates essential for OAT.Utilizing environmentally friendly oxidants such as dioxygen and water aligns with sustainable chemistry principles, promoting efficient catalytic systems.The mechanisms of OAT reactions are elucidated through spectroscopic techniques, revealing insights into the interactions between iron centers and substrates.Challenges related to the instability of high-valent iron species are addressed, highlighting innovative activation strategies that enhance their reactivity and stability.Additionally, the review discusses current inhibitor strategies targeting endosulfatases, particularly sulfamate-containing compounds, which show promise in modulating HS sulfation patterns.By advancing the understanding of iron-mediated catalysis and the development of specific inhibitors, this research underscores the potential for therapeutic applications in diseases characterized by aberrant HS interactions.Future directions aim to refine inhibitor potency and selectivity while exploring targeted drug delivery methods.This exploration not only enhances our comprehension of iron-catalyzed oxidation processes but also paves the way for innovative solutions in glyco-chemistry and biomedicine.
Author: Nasser Thallaj
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4411385573