Work

Asymmetric total syntheses of immunosuppressive diterpenoids triptobenzenes N and R via a remote Csp 3 –H functionalization

Year: 2025

Type: article

Abstract: -H functionalization of an enone intermediate. The highly functionalized dienone intermediate 2 was utilized as a common scaffold for this study. An XRD analysis of compounds 8 and 4 confirmed the stereochemistry of the quaternary centers of the abietane core. Finally, a chemoselective ketal protection and reduction completed the first total syntheses of the immunosuppressive diterpenoids triptobenzenes N (1c) and R (1d).

Source: Chemical Communications

DOI: 10.1039/d5cc02354h

Authors: Nanda Kishore Roy, Ranjit Murmu, Mintu Munda, Sovan Niyogi, Alakesh Bisai

Institutions: Indian Institute of Science Education and Research Kolkata, Indian Institute of Science Education and Research, Bhopal

Language: English

Topic: Biological Activity of Diterpenoids and Biflavonoids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Council of Scientific and Industrial Research, India, Science and Engineering Research Board

Awards: G1901905372, G2143790227, G4801093118, G5847622741, G901785919