Changes in inflammatory composite markers and D-dimer levels in young and middle-aged/elderly patients with hypertriglyceridemic acute pancreatitis and their predictive value for disease progression.
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Hypertriglyceridemic acute pancreatitis (HTG-AP) has a rapid onset and is associated with a high risk of progression and recurrence. Early identification of patients at risk of severe disease can help reduce the likelihood of multiple organ failure and mortality. This study aims to investigate the changes in inflammatory composite markers and D-dimer (D-D) levels in young and middle-aged/elderly patients with HTG-AP and to evaluate their predictive value for disease progression. METHODS: =1 000). RESULTS: =0.321). Internal validation via bootstrap analysis yielded a D-D AUC of 0.732, with sensitivity and specificity of 68.1% and 91.0%, respectively. CONCLUSIONS: Differences in inflammatory response and coagulation function exist across age groups and disease severities in HTG-AP patients. Elevated D-D is an independent predictor of disease progression in both young and middle-aged/elderly patients, while CLR also predicts progression in the latter group. D-D, in particular, demonstrates strong predictive value for severe disease in middle-aged/elderly patients with HTG-AP.
Source: PubMed
Authors: Jing Li, Jinrong Hu, Yuanyuan Gou, Long Yao, Jie Cao
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G695691055
OpenAlex ID: W4411393538