Designed Synthesis and Bioevolution of a Novel Analogous of Thiadiazolo [3, 2-a] Pyrimidine-6- Carboxylate Promoted by Transition Metal Acetates
Year: 2025
Type: article
Abstract: In a novel series of [1, 3, 4] thiadiazol-2-amine, a simple new pathway and biological approach, the analogues of Imidazole [3, 2-a] pyrimidine-6-carboxylate (5a-5q). These analogous were obtained by the reaction of intermediate (3) with ethylacetoacetate and substituted aryl aldehydes in the presence of transition metal acetates, while the reaction between thiosemicarbazide and indole-3-carboxylic acid occurs in the presence of protic acid scaffold compound (3). The newly derived compounds are characterised by advanced spectral analysis, including 1H NMR, 13C NMR, and LC-MS. When compared to a reference medication, the biological potency was excellent, and the results were in line with expectations.
Source: RASAYAN Journal of Chemistry
Authors: S. TirumalaJagadeesh, N.V.S.Venugopal
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4411395300