Electrocardiographic changes in QTc interval and other parameters associated with osimertinib therapy
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Osimertinib, a third-generation EGFR-TKI, is approved for the first-line treatment of EGFR-mutated advanced NSCLC and for T790M-positive NSCLC after progression on previous EGFR-TKI therapy. Osimertinib is associated with cardiotoxicity, including severe QT interval prolongation, which necessitates detailed evaluation due to its increasing use. Methods: This retrospective, single-center study conducted at Jilin University China-Japan Union Hospital evaluated electrocardiographic changes with EGFR-mutated NSCLC treated with osimertinib. The study consecutively included 102 patients diagnosed with NSCLC at the China-Japan Union Hospital of Jilin University from August 1, 2019, to December 31, 2022. Among them, 41 patients who had both pre- and post-treatment ECG records while receiving osimertinib (80 mg daily) were analyzed. ECG parameters such as heart rate, PR interval, QRS duration, QRS axis, and QT intervals were manually calculated and analyzed. Results: = 0.0039), with both QTc Bazett and QTc Fridericia intervals showing notable prolongation. However, the changes in heart rate, PR interval, and QRS duration were not statistically significant. Conclusion: This study comprehensively investigates the electrocardiographic changes before and after osimertinib treatment in patients with EGFR-mutated NSCLC. The significant prolongation of QTc intervals underscores the need for rigorous ECG monitoring to mitigate potential cardiotoxicity.
Source: Frontiers in Oncology
Authors: Yilin Pan, Kexin Peng, Yichuan Jiang, Ping Yang, Beibei Du, Yuquan He
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G1474981084, G5094706750, G6611910476
OpenAlex ID: W4411397238